Author

Z.-H. Gu

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Open access Sep 2026

Integrative Genetic and Single-Cell Analysis Reveals Macrophages as Key Mediators Linking Aging and Osteoporosis

Osteoporosis is a highly prevalent age-related disorder, and accumulating evidence suggests that it does not arise in isolation but is intrinsically linked to the aging process. Here, we employed integrative methods to systematically identify the relationship between aging and osteoporosis, and uncover the critical cel...

X. Li, M.-Y. Yang, Si-Rui Gai et al. · medRxiv · 0 citations

Open access Jan 2026

Evaluating the Causal Roles of Matrix Metalloproteinases in Metabolic Syndrome: A Mendelian Randomization Study Highlighting MMP12 in Blood Pressure Regulation

Purpose This study aims to investigate whether matrix metalloproteinases (MMPs) are associated with the risk of metabolic syndrome (MetS) and its components. Methods We conducted a two‐sample Mendelian randomization (MR) study by using 9 types of MMPs as exposures and MetS and its components (waist circumference, essen...

Qiaohui Qian, Ming Fang, Z.-H. Gu et al. · Genetics Research · 0 citations