tRF-28-ZJ47D112Z4DZ suppresses gastric cancer progression via Ago2-mediated regulation of the CCND1-associated cell cycle pathway and serves as a complementary plasma biomarker.
INTRODUCTION Gastric cancer (GC) remains a leading cause of cancer-related mortality worldwide, highlighting the need for improved non-invasive biomarkers for early detection and prognostic evaluation. tRNA-derived fragments (tRFs) have emerged as regulatory non-coding RNAs in cancer, but their biological and clinical...