Author

Z. Jie

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Jul 2026

Targeting NAE1 suppresses osteoclastogenesis via dual regulation of ferritinophagy and ACSL3-mediated ferroptosis.

These findings support MLN4924, a clinical-stage NAE inhibitor, as a potential therapeutic strategy for osteoporosis and define an Nae1-ACSL3-MUFA-ferroptosis axis regulating osteoclast metabolism.

Hongwei Xie, Jiacheng Xie, Zihan Dai et al. · Autophagy · 0 citations