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Review Open access Aug 2026

Proteostasis breakdown and aggregate diversity in aging and neurodegenerative disease

Protein aggregation and proteostasis decline are central features of aging and neurodegenerative disease, arising from progressive impairment of protein quality-control systems and transitions into aggregation-prone states. During aging, diverse proteins, including metabolic and proteostasis-related factors, gradually...

Z. Khan · 0 citations

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