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Open access Sep 2026

EspO-mediated neutrophil accumulation drives lethality during Citrobacter rodentium infection in interleukin-22-deficient mice

Citrobacter rodentium (CR) is a murine-specific enteric pathogen widely used to model infections of the attaching and effacing pathogens enteropathogenic and enterohaemorrhagic Escherichia coli. Infection induces colonic epithelial damage and inflammation that are resolved in resistant mice but result in severe disease...

Vishwas Mishra, Priyanka Biswas, Z. Kozik et al. · 0 citations
Sep 2026

Abstract PR003: NF1 loss disrupts a SMARCA2–CTCF–H1 chromatin-remodelling axis and creates DNA repair vulnerability in retinoic acid–resistant high-risk neuroblastoma

Neuroblastoma (NB) is an aggressive childhood malignancy arising from the developing sympathetic nervous system. NF1 loss-of-function (LoF) and activating-RAS mutations both result in downstream activation of RAS-pathway signalling, are enriched at relapse, and associated with differentiation block. We show that fail...

Khushboo Agrawal, Z. Kozik, Matthew Shipley et al. · 0 citations

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