Open access
Sep 2026
KCNE3-KCNQ1 ion channel axis orchestrates mitochondrial metabolic reprogramming to couple osteogenesis and angiogenesis in skeletal repair
Findings establish the KCNE3/KCNQ1 axis as a pivotal regulator of skeletal vascular function and mitochondrial energetics during bone repair, highlighting ML277 as a promising therapeutic candidate for fracture nonunion.
Ren-Kai Wang, You Wu, Z. Li et al.
· Cell Death Discovery · 0 citations