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Open access Sep 2026

KCNE3-KCNQ1 ion channel axis orchestrates mitochondrial metabolic reprogramming to couple osteogenesis and angiogenesis in skeletal repair

Findings establish the KCNE3/KCNQ1 axis as a pivotal regulator of skeletal vascular function and mitochondrial energetics during bone repair, highlighting ML277 as a promising therapeutic candidate for fracture nonunion.

Ren-Kai Wang, You Wu, Z. Li et al. · 0 citations

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