Z. Piravar

Cancer-Associated Fibroblast Exosomes in Breast Cancer: Mechanisms of Tumor-Stroma Crosstalk and Clinical Implications.

Breast cancer progression is shaped by a continuous exchange of signals between tumor cells and the surrounding stroma, in which cancer-associated fibroblasts (CAFs) are among the most influential partners. This review concentrates on CAF-derived exosomes as the principal vehicles of that exchange, and on how their car...

Association of miR-326, SIRT1, and HMGA2 Expression in Breast Cancer Cells Exposed to Mesenchymal Stromal Cell-Derived Extracellular Vesicles

Background: Breast cancer progression is influenced by tumor–microenvironment interactions mediated by Extracellular Vesicles (EVs), which transfer bioactive molecules such as microRNAs. This in vitro study investigated the role of miR-326 in modulating SIRT1 (Sirtuin 1) and HMGA2 (High-mobility group AT-hook 2) expres...

Engineered mesenchymal stem cell-derived small extracellular vesicles delivering miR-124 suppress colorectal cancer progression through EZH2 downregulation and attenuation of STAT3 signaling