The dose-response of six months of controlled exercise was studied in 72 subjects aged 50 to 70 years, with 1-4 training sessions per week, focusing on DNA methylation-based aging. Epigenetic age reduction increased with exercise dose, with about 255 MET-hours aligning with a one-year decrease in Robust PhenoAge accele...
F. Torma, M. Jókai, G. Bábszky et al.· medRxiv· 0 citations
A multi-omic framework in which exercise acts as a coordinated biological stimulus capable of remodeling age-associated molecular dysfunction across genomic, epigenomic, transcriptomic, proteomic, and metabolomic layers is proposed, supporting the concept that healthy aging is dynamically regulated and that age-associa...
Guilherme da Silva Rodrigues, I. V. de Sousa, Takuji Kawamura et al.· Physiological Genomics· 0 citations
Intrinsic high aerobic capacity in aged skeletal muscle is associated with hypermethylation-enriched methylome remodeling, feature-dependent functional enrichment, distinct transcriptional signatures, and oxidative-metabolic protein differences.
Lei Zhou, S. Mozaffaritabar, F. Torma et al.· Journal of Sport and Health...· 0 citations
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