Author

Z. P. Rosenthal

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Open access Sep 2026

Response to Electroconvulsive Therapy in a Patient With SCN2A-Variant Catatonia Is Associated With Postictal Spreading Depolarization.

An 18-year-old female patient with a history of autism spectrum disorder and SCN2A loss-of-function variant received a course of electroconvulsive therapy (ECT) for catatonia, which had been present and disabling for 1 year. After a partial lorazepam taper, bitemporal ECT was initiated. The patient had a rapid and robu...

Z. Rosenthal, K. Lad, Reina E. Li et al. · Journal of ECT · 0 citations

Open access Aug 2026

Epilepsy and premature mortality driven by inhibitory neuron dysfunction in a mouse model of SCN1A gain-of-function neurodevelopmental disorder

The first mouse model of SCN1A GoF epilepsy with heterozygous Cre-dependent expression of the recurrent patient variant Scn1a-p.R1636Q is developed, the first study of SCN1A GoF epilepsy in a preclinical model in vivo and further investigation in the Scn1aflox(R1636Q)mouse will yield new mechanistic insights into disea...

Sophie F. Hill, Z. Rosenthal, E. Goldberg · bioRxiv · 0 citations