Author

Z. Rzepka

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Open access Sep 2026

Novel Lomefloxacin–Triazole Hybrids: Design, Synthesis and In Vitro Antiproliferative Activity in Breast, Melanoma and Colon Cancer Cell Lines

In recent years, extensive research has focused on fluoroquinolone–triazole hybrids, with particular emphasis on structural modifications of ciprofloxacin. In the present study, novel derivatives of lomefloxacin with a 1,4-disubstituted-1,2,3-triazole moiety were designed, synthesised, and biologically evaluated at the...

Justyna Nowakowska, Zuzanna Rzepka, A. Bąk et al. · Biomolecules · 0 citations

Jul 2026

Mechanistic insights into EB171 anticancer activity in MCF7 and MDA-MB-231 breast cancer cells showing differential responses.

Breast cancer remains one of the leading causes of cancer-related mortality in women worldwide, with estrogen receptor α (ERα) signaling playing a key role in hormone-dependent tumors. Here, we investigated the molecular basis of the anticancer activity of EB171, an amide derivative of betulonic acid, in breast cancer...

Zuzanna Rzepka, Dominika Stencel, E. Bębenek et al. · Toxicology and Applied Pharm... · 0 citations