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Author

Z. Sethna

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Open access Nov 2026

An information-theoretic framework for inferring T cell dynamics from single-cell RNA and T cell receptor sequencing.

Single-cell T cell receptor (TCR) repertoire sequencing enables simultaneous profiling of gene expression and TCR sequences, providing a coregistered measure of T cell phenotypic diversity and clonal dynamics. However, principled probabilistic frameworks for joint modeling of clonotype and phenotype have remained limit...

N. Ceglia, Sohrab Salehi, Z. Sethna et al. · 0 citations
Open access Jul 2026

Ensembles of in silico structures enable T cell peptide-MHC binding prediction

Adaptive immunity relies on T-cell receptor (TCR) recognition of peptides presented by the major histocompatibility complex (pMHC). Accurate prediction of TCR:pMHC binding pairs from sequence data remains a longstanding challenge in computational immunology, limiting the development of precision immunotherapies like ca...

O. Lyudovyk, JA Levine, M. Pathil et al. · 1 citation

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