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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Z. Sui

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Review Open access Jul 2026

ADAM12 in a stromal-checkpoint framework: integrating tumor microenvironment remodeling and therapy resistance in solid tumors

An integrative stromal-checkpoint framework is used to describe stromal programs that couple extracellular matrix remodeling, metabolic stress, vascular dysfunction, and immune exclusion into treatment-resistant tumor ecologies and discusses how ADAM12-informed biomarkers, spatial barrier profiling, and stromal-priming...

Shao-Chun Liu, Jian Xu, Han Zhang et al. · 1 citation

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