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Author

Z. Tarcan

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Sep 2026

Abstract B009: Invasion status parses composition of the human pancreatic cancer perineural niche

The peripheral nervous system innervates the pancreatic ductal adenocarcinoma (PDAC) microenvironment, and perineural invasion (PNI) of cancer cells correlates with metastatic burden and poor outcomes. Though PDAC innervation is near-universal and the majority of PDAC patients harbor PNI, the cellular and molecular c...

Zainab Hussain, Dig Vijay Kumar Yarlagadda, Qian-Zi Li et al. · 0 citations
Open access Sep 2026

Neoantigen-reactive CD8+ T cell engagement marks exceptional survivors of pancreatic cancer

Pancreatic cancer (PC) is largely refractory to immune checkpoint blockade (ICB), although homologous recombination-deficient (HRD) tumors may derive benefit. In the POLAR trial of maintenance pembrolizumab plus olaparib after platinum-based chemotherapy for metastatic PC, responses remained heterogeneous. To define de...

M. Hilmi, J. Schoenfeld, Wilson H. McKerrow et al. · 0 citations
Open access Aug 2026

Evolutionarily conserved epigenetic regulation of transcriptional cell states during vertebrate pancreatic tumorigenesis.

These findings suggest a highly conserved role for HDAC9 and class IIA HDACs in vertebrate pancreatic tumorigenesis and may lead to new strategies for reactivating (normal acinar/epithelial) differentiation programs to intercept and treat PDAC.

Somer Matar, Sandra Blázquez-Araguás, Andrea Diéguez-Docampo et al. · 1 citation

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