Author

Zachary J Roberts

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Sep 2026

Cellular and molecular mechanisms determining allogeneic CAR T cell rejection and expansion.

High frequencies of pre‑existing, recipient-derived alloreactive CD8+ T cells mediated rapid CAR T rejection in non-expanders and effector-like features, rather than stem/central memory programs, drove robust clonal CAR T expansion consistently across expanders.

A. Jallouk, Zhong-Qi Ge, V. Kaimal et al. · Cancer Discovery · 0 citations

Open access Jul 2026

Allogeneic CD70-Targeted Chimeric Antigen Receptor T-Cell Therapy for Advanced Renal Cell Carcinoma: Results From the Phase I TRAVERSE Trial

The TRAVERSE trial demonstrates proof of concept for the role of allogeneic CAR T-cell therapy in solid tumors and had manageable safety and encouraging antitumor activity in CD70-positive ccRCC.

S. Srour, J. Chahoud, A. Drakaki et al. · Journal of Clinical Oncology · 0 citations