Author

Zaheer ul‐Haq

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Sep 2026

Synthesis and Biological Evaluation of Imidazo‐Thiadiazole‐Linked Benzisoxazole Hybrids as Dual α ‐Glucosidase and α ‐Amylase Inhibitors With Antioxidant Potential

Type 2 diabetes mellitus (T2DM) remains a major global health challenge, necessitating the discovery of novel therapeutics with improved safety and efficacy. In this study, a series of imidazo‐thiadiazole‐linked benzisoxazoles ( 1–20 ) was synthesized and evaluated for dual inhibitory activity against α ‐glucos...

Mehwish Solangi, Komal Solangi, M. Özil et al. · ChemistrySelect · 0 citations

Open access Aug 2026

Design and synthesis of quinoline-derived thioureas as potential antihyperglycemic, anti-Alzheimer, and antioxidant agents

A library of quinoline-based thiourea hybrids 1–41 was synthesized via a single-step reaction scheme. All compounds were evaluated for their inhibitory potential against α-amylase, α-glucosidase, AChE, and BChE enzymes as well as for DPPH radical scavenging activity. Among forty-one compounds, 27–31 and 33–37 showed ex...

Faiza Seraj, Maryam Maqbool, F. Ali et al. · RSC Advances · 0 citations

Jul 2026

Naphthoquinones mediate differentiation of human umbilical cord derived mesenchymal stem cells into insulin producing cells through regulation of Wnt and BMP pathways

The regulatory role of lawsone and lapachol can be exploited for preconditioning of MSCs for improved pancreatic β-cell differentiation, as well as regulating downstream Wnt and BMP signaling.

Javeria Masnoon, Aisha Ishaque, Irfan Khan et al. · BioImpacts · 0 citations