Author

Zak T. Janetzki

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Open access Jul 2026

Addressing viral genomic variability towards developing a Cas13b-based therapy

The findings show that a “one size fits all” approach for PspCas13b-mediated treatment of HBV is unlikely to be effective, but the impact of sequence variability on PspCas13b efficacy can be readily addressed through appropriate design of crRNAs.

Mai Anh Thu Le, L. McCoullough, Zak T. Janetzki et al. · bioRxiv · 0 citations