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Zarkadas Elefterios

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Open access Jul 2026

The immunosuppressant tacrolimus (FK506) inhibits C. glabrata Cdr1 efflux pump function by stabilizing the inward-facing conformation

CryoEM structure of CgCdr1 in complex with FK506 revealed that FK506 binds within the drug-binding site of CgCdr1, occupying the space occupied by Itraconazole, demonstrating that FK506’s inhibition extends beyond competitive binding, involving allosteric modulation of the ATPase cycle.

Baccouch Rim, Benefice Theo, Zarkadas Elefterios et al. · 0 citations

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