CNOT4 Suppresses Bladder Cancer Progression by Promoting Ubiquitination-Mediated Degradation of EIF2AK2 and Inhibiting Autophagy.
EIF2AK2, also known as PKR, is a stress-responsive kinase that regulates multiple cellular processes, including autophagy, apoptosis, and tumor progression. However, the mechanisms underlying EIF2AK2 stability and function in bladder cancer (BLCA) remain underexplored. In this study, we investigated the mechanisms gove...