Identification of Secreted Modular Calcium-Binding Protein 1 as a Novel Endogenous Protective Molecule Against Acute Myocardial Infarction-Induced Cardiac Rupture.
BACKGROUND Cardiac rupture is a catastrophic complication of acute myocardial infarction (AMI), with poorly understood molecular mechanisms and no available therapeutic interventions. METHODS Plasma samples were obtained from patients with AMI and animal models, while left ventricular tissue was collected from AMI mi...