Open access
Jul 2026
Hypoxia tumor-associated macrophages facilitate hepatocellular carcinoma metastasis via uPA-uPAR pathway.
Hypoxia drives TAM heterogeneity in HCC via an H‑TAM‑intrinsic HIF‑1α-uPA axis that engages uPAR on HCC cells to promote metastasis, and dasatinib is a promising therapy to block this axis and improve outcomes.
Yi-Jun Wang, Xiaomin You, Xiangyuan Luo et al.
· Journal of Translational Med... · 0 citations