Ze-Yan Jiang

A novel conformationally constrained RGD-based cyclic peptide targeting integrin αvβ6 protein for antitumor therapeutic applications.

The arginine-glycine-aspartic acid (RGD) tripeptide sequence is widely distributed in extracellular matrix proteins enabling efficient targeting of integrin receptors that are overexpressed on the surface of tumor cells, thereby facilitating the selective delivery of therapeutic molecules to tumor tissues. Cyclic RGD p...