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Author

Zekun Deng

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Open access Oct 2026

TOP2A Overexpression as a Prognostic Biomarker in High-Grade Meningioma: An Integrated Single-Cell and Bulk Transcriptomic Study

While prior single-cell studies have identified proliferative neoplastic subpopulations, the prognostic and therapeutic implications of TOP2A focal copy-number status have not been defined. This study aimed to delineate the cellular architecture of high-grade meningioma and to evaluate the clinical and prognostic signi...

Hong-Qing Cai, Guan-Chao Xie, Hou-Jie Liu et al. · 0 citations
Jul 2026

Growth Hormone and Cancer Risk: A Two-Sample Bidirectional Mendelian Randomization Study with Mediation Testing.

These findings demonstrate tissue-specific effects of GH on carcinogenesis, partially mediated through metabolic pathways, and suggest metabolite monitoring could help mitigate cancer risk in susceptible individuals.

Zeming Yan, Yunzhi Zou, Yiguang Chen et al. · 0 citations

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