Identification of Nesfatin-1 in Primitive Vertebrate Lampreys and Its Roles in Inflammatory Responses and Ferroptosis.
Nesfatin-1 is an 82-amino acid polypeptide derived from the precursor protein nucleobindin 2 (NUCB2), which is a conserved multifunctional peptide in vertebrates that plays a key role in metabolic regulation, inflammatory response and ferroptosis. Although Nesfatin-1 has been characterized in various vertebrates, from...