ZEB1 orchestrates cellular plasticity and therapy resistance in prostate cancer: from molecular mechanisms to clinical targeting.
Prostate cancer (PCa) is a leading cause of male cancer mortality worldwide. Its treatment failure is predominantly driven by the transition to castration-resistant phenotype (CRPC). Zinc finger E-box binding homeobox 1 (ZEB1) is a master inducer of epithelial-mesenchymal transition and has emerged as a central orchest...