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Author

Zhan Zhang

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Jul 2026

STAT6 Targets the Autophagy Pathway to Regulate Microglial Senescence in Cognitive Impairment Caused by Cerebral Small-Vessel Disease

Mechanistically, it was found that phosphorylated STAT6 (pSTAT6) enhanced autophagy, which reduced the burden of senescent microglia and thereby ameliorated CSVD-induced VCI, providing insights into the potential of targeting the STAT6 pathway in VCI associated with CSVD.

Xiaolu Liu, Qing Liu, Jingwen Yang et al. · 0 citations
Jul 2026

Photobiomodulation of immune crosstalk rescues neuroinflammation in Alzheimer's disease models.

It is suggested that the PBM-induced modulation of crosstalk between microglia, astrocytes, and CD8+ T cells is closely related to cognitive improvement, which resolves neuroinflammation and restores cognition in AD models-a translatable strategy for combating neurodegeneration.

Qi Shen, Hao-Cai Chang, Junyu Li et al. · 0 citations

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