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Zhangzhi Xiong

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#artificial intelligence Preprint Oct 2026

CryoAtlas: A Large Curated Dataset and Unified Benchmark for Cryo-EM Atomic Model Building

This work introduces CryoAtlas, a rigorously curated dataset and unified benchmark for density-guided atomic model building of protein chains, and constructs a 618-target benchmark with a shared evaluation protocol that jointly assesses structural accuracy, model-to-map fit, and stereochemical validity.

Ming-Rui Li, Min-Zhang Li, Wei-Chen Qin et al. · 0 citations
Jul 2026

Evolution-Aware MSA Reasoning for Subsampling via Factor Graphs

Experiments show that AP-REASONER outperforms baseline subsamplers on structure-sensitive downstream tasks and enables controllable recovery of alternative protein conformations, highlighting the value of modeling MSA subsampling as a controllable optimization problem, where factor-graph reasoning offers an effective a...

Zhangzhi Xiong, Min-Zhang Li, Hao Yu et al. · 0 citations

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