Author

Zhangquan Yang

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Open access Aug 2026

Method Choice, Not Biology, Determines In Silico Perturbation Results: A Systematic Evaluation of Eight Methods Across Four Datasets

Computer methods that simulate gene knockout experiments from single-cell RNA sequencing data are increasingly popular, but researchers lack guidance on which method to choose, so preliminary guidance for method selection is established, including cross-pathway validation, direction-aware benchmarking, and minimum data...

Shixiang Wu, Gang Hu, Zhang-Quan Yang et al. · bioRxiv · 0 citations

Open access Jul 2026

NKD1 promotes the progression and 5-FU resistance of colorectal cancer via the Wnt/β-catenin signaling.

Naked cuticle homolog 1 is established as a key regulator of CRC malignancy and chemoresistance via Wnt/β-catenin pathway activation, supporting its potential as a dual biomarker and therapeutic target in combination regimens.

Lingyi Dong, Zhangquan Yang, Zelin Xu et al. · Cell Death and Disease · 0 citations