Open access
Jul 2026
Harnessing the PpHog1 Regulatory Network to Engineer a UPR‐Adaptive Komagataella phaffii Chassis for High‐Copy Secretory Protein Production
An engineered UPR‐adaptive chassis (UPR‐Ad+) was constructed by over‐expressing these three key regulators and enhanced the production of high‐copy secretory proteins by 30%–46%.
Jiacheng Shi, Zhanqing Lv, Chaoyu Lu et al.
· Microbial Biotechnology · 0 citations