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Author

Zhao-Fu Li

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Review Open access Sep 2026

Damage-Associated Molecular Patterns and Trained Immunity of Monocyte–Macrophage Populations in Osteoarthritis: Potential Molecular Links and Therapeutic Opportunities

Osteoarthritis (OA) is now widely discussed as a whole-joint immunometabolic disease involving cartilage, synovium, and subchondral bone, rather than as cartilage degeneration driven only by mechanical stress. Tissue injury, cell death, mitochondrial dysfunction, and extracellular matrix degradation can lead to the per...

Jian Zhang, Bing-Bing Chen, Yun-Dong Xu et al. · 0 citations
Review Open access Aug 2026

Signaling pathways and ion channels in osteoarthritis: a review of recent advances

The understanding of osteoarthritis (OA) has gradually evolved from the traditional perspective of it being a mere “wear-and-tear” joint disease to a more comprehensive view that characterizes it as a degenerative joint disease marked by chronic low-grade inflammation and immune imbalance. The progression of OA is clos...

Xi Liu, Ni-Qing Xiao, Qiumei He et al. · 0 citations

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