ROS-Responsive siFGF19 Delivery Reprograms Pancreatic Stellate Cells and Remodels the Desmoplastic Microenvironment in Pancreatic Cancer
Background: Pancreatic ductal adenocarcinoma (PDAC) is characterized by extensive stromal fibrosis that limits drug delivery and promotes therapeutic resistance. Pancreatic stellate cells (PSCs), key mediators of desmoplasia, represent a promising yet underexploited therapeutic target. This study aimed to suppress PSC...