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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Zhao‐Jun Wei

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Aug 2026

Targeting the PLEC/TPM4 cytoskeletal axis: DT-13 inhibits colorectal cancer metastasis through direct binding to PLEC and inactivation of Akt/ERK signaling.

DT-13 exerts anti-metastatic effects in CRC by disrupting the PLEC/TPM4 cytoskeletal scaffold and suppressing the epithelial-mesenchymal transition process, highlighting the clinical potential of DT-13 as a safer therapeutic alternative for patients with metastatic CRC.

Jing-Yu Feng, Jing-Ling Yang, Rui Zhang et al. · 0 citations

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