HK2 drives synaptic dysfunction in fragile X syndrome via epigenetic regulation of H3K18 lactylation
Introduction Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by loss of fragile X messenger ribonucleoprotein (FMRP) expression and characterized by synaptic dysfunction and cognitive impairment. However, the metabolic and epigenetic mechanisms underlying these abnormalities remain poorly understood. T...