Author

Zhao Zhang

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Open access Oct 2026

A Germline-Encoded lncRNA-Mitochondrial Axis Rewires Oxidative Phosphorylation to Drive Progression in Clear Cell Renal Cell Carcinoma.

Clear cell renal cell carcinoma (ccRCC) is characterized by profound metabolic reprogramming and substantial inherited susceptibility. The molecular mechanisms linking germline risk variation to tumor metabolic reprogramming could potentially be exploited for precision interventions. Here, we aimed to delineate the ger...

Guo-Wen Duan, Wen-Jie Xu, Wen-Jun Jiang et al. · Cancer Research · 0 citations

Open access Oct 2026

Comprehensive characterization of transposable element expression reveals regulatory circuitry and clinical implications in cancers

Transposable elements (TEs) constitute nearly half of the human genome and have crucial roles in regulatory networks and clinical utility in cancers. However, the expression profiles at a single-element resolution remain unexplored. By integrating multiomics data from ∼10,000 samples and 1000 cancer cell lines, we esta...

Wei Hu, Wen-Jun Jiang, Ze-Hua Gao et al. · Science Advances · 0 citations

Open access Sep 2026

Targeting CTGF+ cancer-associated fibroblasts disrupts tumor-stroma crosstalk in pancreatic ductal adenocarcinoma.

Targeting CTGF+ CAFs with QX03-46 significantly disrupted the CTGF/TGF-β1 signaling axis and suppressed CAF functions, resulting in decreased extracellular matrix deposition and oncogenic cytokine secretion and position QX03-46 as a promising therapeutic candidate for targeting the fibrotic TME.

Yi-Wen Shen, Qing-Yan Sun, Yun-Zhe Wang et al. · Proceedings of the National... · 0 citations