Author

Zhaochen Shan

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Open access Jul 2026

IL-34 Regulates Macrophage Polarization and Bone Defect Healing in Aged Mice

Aging is a major risk factor for impaired bone-defect healing, and dysregulation of the immune microenvironment, especially macrophage dysfunction, is closely linked to this process. Interleukin-34 (IL-34) plays a crucial role in macrophage biology; however, its role in aging-related bone-defect healing remains elusive...

Wen-Yan Pan, Shengao Qin, Zanxu Liu et al. · International Journal of Mol... · 0 citations

Review Open access Aug 2026

New Immunological Insights into Bisphosphonate-Related Osteonecrosis of the Jaw: A Multidimensional Reappraisal from Molecular Switches to Clinical Phenotypes

Bisphosphonates (BPs) are cornerstone therapeutic agents for the management of metabolic bone disorders and skeletal complications associated with malignant tumors. However, their long-term administration is accompanied by the risk of developing bisphosphonate-related osteonecrosis of the jaw (BRONJ). In recent years,...

Yao Li, Shengao Qin, Jiaqi Wang et al. · Current Issues in Molecular... · 0 citations