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Author

Zhaoqi Yang

2 papers indexed here

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Aug 2026

Structure-Optimized Asymmetric siRNA Increases Predicted AGO2 Binding Affinity to Augment Targeted MMP7 Gene Silencing Efficacy.

RNAi holds significant therapeutic potential, yet the clinical efficacy of siRNA drugs has been constrained by challenges in stability, targeted accumulation, and efficient loading into the RISC. To address this, we hypothesized that rationally extending or shortening the terminal base of the siRNA antisense strand cou...

Shixu Kou, Yuxuan Qian, Xuefeng Ding et al. · 0 citations
Sep 2026

Glutathione-Driven Redox Inducer with Disruption of the SLC7A11/GSH/GPX4 Axis for Enhanced Ferroptotic Therapy

A glutathione-responsive metal–organic framework nanoplatform for the co-delivery of curcumin and a GPX4-targeting antisense oligonucleotide (ASO) demonstrated robust anticancer effects in 3D multicellular tumor spheroids with a promoted oxidative imbalance.

Sen Li, Wen-Tao Wang, Yi-Zhang Chen et al. · 0 citations

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