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Author

Zhaoxia Yin

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Jul 2026

Abstract B040: Hold-to-Kill: RIPTAC Expanding Induced Proximity from Target Engagement to Therapeutic Window

RIPTAC (Regulated Induced Proximity Targeting Chimeras) introduces a novel strategy that leverages induced proximity to achieve selective cancer cell killing. Using AR-BRD4 RIPTAC II-5 as a tool compound, we integrated biochemical screening, computational docking, and multi-level cellular and in vivo assays to establ...

Qing Xue, Zhuo Meng, Xuebing Yang et al. · 0 citations

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