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Author

Zhe Chen

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Oct 2026

Structural evolution of an ancient nucleotidyltransferase underlies divergence of AbiE antitoxins.

Type VII toxin-antitoxin (TA) systems neutralize toxins through antitoxin-mediated post-translational modification (PTM), with the oligoAMPylation-based HepT/MntA and phosphorylation-based AbiE systems representing the most prevalent families. Although the AbiE TA system from Mycobacterium tuberculosis is known to empl...

Tian-Lang Liu, Ran Chen, Kai-Hao Tang et al. · 0 citations
Open access Oct 2026

A phospholipase B effector exploits membrane lipid divergence to drive inter-Bacteroides competition and enables universal genome editing

ABSTRACT The Type VI secretion system (T6SS) mediates interbacterial competition, yet the mechanisms underlying its effector diversity and cell-targeting specificity remain poorly understood. Here, we identify Btle, a phospholipase B (PLB) effector defining a unique Tle subfamily (Tle7), encoded in approximately 18.0%...

Xiao-Ning Xu, Zhe Chen, Jing He et al. · 0 citations

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