Metabolic reprogramming forms the foundation of immune effector functions and the regulation of inflammation. As a pivotal node connecting the tricarboxylic acid cycle to immune signaling, the IRG1/ACOD1 and itaconate axes play a central role in coordinating inflammatory tone and redox balance. Itaconate, generated thr...
Jian-You Gu, Wen-Ying Zhang, Jun-Feng Zhang et al.· Signal Transduction and Targ...· 0 citations
Cancer-associated fibroblasts (CAFs) are key components of the tumor microenvironment and contribute substantially to gastric cancer progression. However, the phenotypic and functional heterogeneity of CAFs in gastric cancer remains incompletely characterized. Here, we analyzed single-cell transcriptomic data from gast...
Yu-Sheng Luo, L. Zhong, Ke-An Mu et al.· Cancer Genetics· 0 citations
Current cancer treatment still relies largely on stage-specific diagnosis and relatively fixed therapeutic regimens, while diagnostic information, therapeutic intervention, and efficacy feedback are often separated across different time windows. This fragmentation limits the ability to meet the demands of precision and...
Xuan-Ming Mao, Ming-Yu Cui, Lu-Qi Cao et al.· Soft Science· 1 citation
Berberine (Ber), a bioactive isoquinoline alkaloid derived from traditional Chinese herbs, has shown protective effects against sepsis-associated myocardial injury, although its underlying mechanisms remain unclear. This study investigated whether Ber attenuates LPS-induced myocardial injury by preserving mitochondrial...
Ze-Lin Li, Ji-Hong Liu, Qi Shen et al.· Pathology, Research and Prac...· 0 citations
Multidrug resistance (MDR) remains a major challenge in cancer treatment. MDR has been explained by single-gene mechanisms, such as overexpression of ATP-binding cassette (ABC) transporters, drug-target mutations, activation of bypass signaling pathways, and increased DNA repair. However, these mechanisms alone are ins...
Xiang Chen, Qin-Guo Huang, Ryan Li et al.· Pharmacology and Therapeutic...· 0 citations
This review outlines molecular, cellular, and microenvironmental adaptations in cancer RT that confer enhanced chemotherapy resistance in cancer cells surviving from ionizing radiation (IR), and summarizes mechanisms and emerging strategies for drug resistance in cancer RT.
Yang Chen, Chao-Yun Cai, Xiao-Cheng Xu et al.· Pharmacological Research· 0 citations
A comprehensive analysis of the molecular structure of ADCs, the pharmacological principles underlying their potent cytotoxic activity against MDR cancer cells, the genomic and transcriptomic biomarkers that guide ADC patient selection, and the emerging resistance mechanisms that will shape the next generation of promi...
Ryan Li, Xiang Chen, Qin-Guo Huang et al.· Cancer Letters· 0 citations
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