Zhe Tang

Molecular innate immune programs of tumor-associated macrophages in immune checkpoint blockade resistance: a staged framework from suppressive circuitry to translational bottlenecks

Immune checkpoint blockade (ICB) has reshaped the treatment landscape for many malignancies, yet only a subset of patients achieve durable clinical benefit. Both primary and acquired resistance remain major barriers to long-term disease control. As central innate immune cells in the tumor microenvironment, tumor-associ...