Zhe-Yi Zhou

CAR-based therapies in systemic autoimmunity: from deep immune depletion toward durable immune reset.

Systemic autoimmune diseases are sustained by self-renewing networks of autoreactive B cells, antibody-secreting cells, pathogenic T-cell programs and tissue-resident inflammatory niches. Conventional immunosuppression and biologic therapy can reduce disease activity, but often fail to produce durable drug-free remissi...