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Zhe Zhuang

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Jul 2026

Abstract A054: Molecular glue discovery enabled by targeted degron display

A range of potent molecular glue degraders that recruit previously unligandable ubiquitylating factors for multiple therapeutically relevant epigenetic regulators and kinases are identified by leveraging mechanisms such as electrophilic covalent bonding, electrostatic interactions, or cation-pi interactions.

Zhe Zhuang · 0 citations

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