Zhen-De Su

Structure-based design and immunogenicity of an H5 hemagglutinin stem nanoparticle vaccine candidate.

Highly pathogenic avian influenza viruses (HPAIVs), particularly the H5N6 subtype, pose a serious global public health threat. Conventional influenza vaccines primarily target the highly variable globular head of hemagglutinin (HA), resulting in limited breadth of protection. Here, we employed a structure-guided vaccin...