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Open access Sep 2026

Functional identification of two cytochrome P450 enzymes involved in diterpenoid oxidation in Ginkgo biloba

Ginkgo biloba is a globally renowned medicinal plant. Ginkgo produces structurally unique diterpene metabolites, of which ginkgolides are the most representative bioactive compounds. Although the ginkgo genome contains a large and diverse family of cytochrome P450s (CYPs), only a few CYPs involved in the early steps...

Lu Chen, Yue Zhang, Zhen Fan et al. · 0 citations
Open access Aug 2026

Genome-guided discovery of clavaic acid, a decalin-containing polyketide encoded by a LovB-like polyketide synthase

Functional analysis of the condensation domain in vivo demonstrated that it is essential for clavaic acid biosynthesis, and expands the understanding of LovB-like iPKSs and establishes this enzyme family as a promising source of cryptic fungal polyketides.

Yu Ping, Zainab Batool, Zhen Fan et al. · 0 citations

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