Chimeric antigen receptor (CAR) T cells show limited efficacy in solid tumors due to suppressive factors in the tumor microenvironment. In this study, we identified extracellular magnesium (Mg2+) as a pharmacologically modulable regulator of CAR T activity. Mg2+ supplementation increased early activation and augmented...
Jun-Lin Li, Xu-Tao Liu, En Ren et al.· ACS Applied Materials and In...· 0 citations
Inspired by the catechol-lysine synergy and oxidative cross-linking mechanisms in mussel adhesion, we have synthesized poly-l-lysine (PLL) modified with 3,4-dihydroxyphenylacetic acid (DOPAC) to encapsulate insulin crystals. Upon oxidation, a dense, stable, and uniform membrane with nanochannels is in situ formed on th...
Jian-Chang Xu, Yanfang Wang, Jingyi Chen et al.· Journal of the American Chem...· 0 citations
An overview of the applications of AI in drug delivery is highlighted, focusing on AI-designed drug formulations, AI-driven prediction of ADMET properties, and AI-assisted drug delivery devices, which support the development of precision medicine.
Xinmin Yu, Xinyun Jiang, Tao Sheng et al.· ACS Nano· 1 citation
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