Review
Open access
Aug 2026
OTULIN: a master regulator of linear ubiquitin homeostasis in immune signaling, inflammation, and disease
OTU deubiquitinase with linear linkage specificity (OTULIN) is the only deubiquitinase known to exhibit strict specificity for Met1-linked linear ubiquitin chains, serving as a critical regulator that restrains linear ubiquitin chain assembly complex and maintains inflammatory homeostasis and tissue integrity. Advances...
Ziyu Zhang, Jiahang Lyu, Yujie Bai et al.
· Frontiers in Immunology · 0 citations