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Author

Zhen-Hong He

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Open access Oct 2026

Inclisiran ameliorates diabetes-associated skeletal muscle remodeling through modulation of FOXO1/PDK4 and ER stress-UPR signaling

Type 2 diabetes mellitus (T2DM) is accompanied by pathological alterations in skeletal muscle, yet effective therapeutic strategies targeting these alterations remain limited. Current interventions, including exercise and nutritional supplementation, often exhibit poor long-term adherence and limited efficacy under...

Zhen-Hong He, Han-Yu Li, Lin-Min Ran et al. · 0 citations
Review Open access Aug 2026

Shared mechanisms of musculoskeletal dysfunction in type 2 diabetes mellitus: Insights into future therapeutic directions (Review)

Although the manifestations of T2DM differ among skeletal muscle, tendon, TBI and bone, these tissues share common pathological drivers, including metabolic dysregulation, chronic inflammation, oxidative stress, extracellular matrix remodeling, and impaired regenerative capacity.

Zhen-Hong He, Han-Yu Li, Yu-Han Luo et al. · 1 citation

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