Zhen-Hua Liu

Cornuside, a core bioactive of Cornus officinalis , alleviates oxidative stress by directly binding CDK2 to activate NRF2/NQO1

Through this systematic screening and validation pipeline, cornuside was conclusively identified as the key antioxidant constituent of C. officinalis that mitigates oxidative stress and apoptosis by directly targeting CDK2 to activate the NRF2/NQO1 pathway, providing a robust pharmacological basis for its functional ap...