Open access
Aug 2026
CAF-derived TGF-β1 activates an LBH-mediated β-catenin stabilization program to drive gastric cancer progression
It is shown that the transcriptional cofactor LBH drives mutation-independent Wnt activation and malignant progression in GC via a tumour microenvironment-regulated post-translational stabilization mechanism, elucidate a critical tumour–stroma crosstalk mechanism and establish the targeted disruption of the LBH–β-caten...
Zhi-Xiong Su, Guifeng Zhang, J. Zhong et al.
· Cell Death & Disease · 0 citations