Forsythiaside A suppresses PANoptosis to alleviate senecionine-induced hepatotoxicity.
ETHNOPHARMACOLOGICAL RELEVANCE Senecio scandens Buch.-Ham. ex D.Don (Qianliguang) is widely used in China, but its clinical application is limited due to the presence of pyrrolizidine alkaloids (PAs), which are well-known natural hepatotoxins. Forsythia suspensa (Thunb.) Vahl (Lianqiao), traditionally applied for heat-...