Author

Zhen-Ming Lei

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Open access Sep 2026

The transcriptional regulator CueR positively regulates the expression of the cueRA operon to maintain copper homeostasis in Pseudomonas chlororaphis zm-1

ABSTRACT Copper serves as an indispensable trace element in living organisms, playing pivotal roles in fundamental physiological processes including enzyme assembly, antioxidant defense, and metabolic regulation. However, excess copper can induce oxidative damage. MerR-family regulator CueR acts as the core mediator of...

Zhong-Kang Wang, Chen Li, Zhen-Ming Lei et al. · Microbiology spectrum · 0 citations

Open access Oct 2026

Metabolic Engineering of Yarrowia lipolytica for De Novo Biosynthesis of Umbelliferone

Umbelliferone, a key precursor for the biosynthesis of high-value furanocoumarin derivatives, is produced via the shikimate pathway. The oleaginous yeast Yarrowia lipolytica possesses an inherently robust shikimate pathway; however, de novo biosynthesis of umbelliferone in this microbial chassis has not been realized t...

Feng-Liu Lu, Ying Luo, Zhen-Ming Lei et al. · Biomolecules · 0 citations